Perinatal asphyxia of full-term newborns: from pathophysiology to long-term outcomes

The fetal environment and circulatory patterns are very different from that of extrauterine life. fetus evolved to thrive grow in a relative hypoxemic adapted several mechanisms response changes oxygen concentration the blood ensure optimal delivery brain heart. However according estimates World Health Organization world 4 9 million newborns born annually state perinatal asphyxia. In economically underdeveloped countries, this indicator is higher than developed but general, frequency asphyxia remains at rather high level modern world. Perinatal or hypoxic-ischemic encephalopathy, can cause multiple organ dysfunction neonatal period, severe diseases future, lead disability infant mortality. characterized by violation gas exchange, which varying degrees hypoxia, hypercapnia acidosis, depending on duration degree interruption air flow, however, obstructed exchange does not have precise biochemical criteria. addition, exact pathophysiology been fully studied, as result “gold standard” treatment an active area research. publication reflects views main stages pathogenesis asphyxia, shows circulation during presents current data emerging disorders newborn’s body against background hypoxic ischemic encephalopathy.